摘要:[目的]观察核因子-κB(NF-κB)抑制剂吡咯烷二硫代氨基甲酸盐(PDTC)对小鼠肝癌Hca-F细胞生长的影响。[方法]用含PDTC的完全培养基体外培养Hca-F细胞,用MTT法测Hca-F细胞增殖抑制率。体内实验中所有小鼠均接种Hca-F并随机分为两组:攻击对照组腹腔注射生理盐水,PDTC治疗组腹腔注射PDTC溶液,每天测量肿瘤体积和体重。治疗后第10天处死小鼠,取肿瘤组织。用MDA试剂盒测定瘤组织MDA含量,用放射免疫法测定肿瘤组织TNF-α的含量。[结果]PDTC在体外可抑制Hca-F增殖,浓度为25μg/mL时细胞增殖抑制率为85.4%。体内实验中PDTC治疗组小鼠肿瘤体积及重量、瘤组织匀浆MDA和TNF-α含量,与对照组比较差异均无显著性意义(P〉0.05)。[结论]PDTC在体外对肝癌细胞增殖有抑制效应。
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