Journal Of Gene Medicine

The aims and scope of The Journal of Gene Medicine include cutting-edge science of gene transfer and its applications in gene and cell therapy, genome editing with precision nucleases, epigenetic modifications of host genome by small molecules, siRNA, microRNA and other noncoding RNAs as therapeutic gene-modulating agents or targets, biomarkers for precision medicine, and gene-based prognostic/diagnostic studies.

Key areas of interest are the design of novel synthetic and viral vectors, novel therapeutic nucleic acids such as mRNA, modified microRNAs and siRNAs, antagomirs, aptamers, antisense and exon-skipping agents, refined genome editing tools using nucleic acid /protein combinations, physically or biologically targeted delivery and gene modulation, ex vivo or in vivo pharmacological studies including animal models, and human clinical trials.

Papers presenting research into the mechanisms underlying transfer and action of gene medicines, the application of the new technologies for stem cell modification or nucleic acid based vaccines, the identification of new genetic or epigenetic variations as biomarkers to direct precision medicine, and the preclinical/clinical development of gene/expression signatures indicative of diagnosis or predictive of prognosis are also encouraged.

《基因医学杂志》的目标和范围包括基因转移的前沿科学及其在基因和细胞治疗中的应用、使用精准核酸酶的基因组编辑、小分子对宿主基因组的表观遗传修饰、siRNA、microRNA 和其他非编码 RNA 作为治疗性基因调节剂或靶标、精准医学的生物标志物以及基于基因的预后/诊断研究。

主要关注领域包括新型合成和病毒载体的设计、新型治疗性核酸（如 mRNA、修饰的 microRNA 和 siRNA）、微小RNA拮抗剂、适体、反义和外显子跳跃剂、使用核酸/蛋白质组合的精细基因组编辑工具、物理或生物靶向递送和基因调节、体外或体内药理学研究（包括动物模型）和人体临床试验。

论文介绍了基因药物转移和作用机制的研究、干细胞修饰或核酸疫苗新技术的应用、新基因的鉴定或表观遗传变异作为生物标志物来指导精准医疗，并鼓励指示诊断或预测预后的基因/表达特征的临床前/临床开发。

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