Circulation-genomic And Precision Medicine SCIESCI

Circulation: Genomic and Precision Medicine considers all types of original research articles, including studies conducted in human subjects, laboratory animals, in vitro, and in silico. Articles may include investigations of: clinical genetics as applied to the diagnosis and management of monogenic or oligogenic cardiovascular disorders; the molecular basis of complex cardiovascular disorders, including genome-wide association studies, exome and genome sequencing-based association studies, coding variant association studies, genetic linkage studies, epigenomics, transcriptomics, proteomics, metabolomics, and metagenomics; integration of electronic health record data or patient-generated data with any of the aforementioned approaches, including phenome-wide association studies, or with environmental or lifestyle factors; pharmacogenomics; regulation of gene expression; gene therapy and therapeutic genomic editing; systems biology approaches to the diagnosis and management of cardiovascular disorders; novel methods to perform any of the aforementioned studies; and novel applications of precision medicine. Above all, we seek studies with relevance to human cardiovascular biology and disease.

流通：基因组学和精准医学考虑所有类型的原创研究文章，包括在人类受试者、实验室动物、体外和计算机中进行的研究。文章可能包括以下研究：临床遗传学应用于单基因或寡基因心血管疾病的诊断和管理；复杂心血管疾病的分子基础，包括全基因组关联研究、基于外显子组和基因组测序的关联研究、编码变异关联研究、遗传连锁研究、表观基因组学、转录组学、蛋白质组学、代谢组学和宏基因组学；将电子健康记录数据或患者生成的数据与上述任何方法（包括表型关联研究）或环境或生活方式因素相结合；药物基因组学；基因表达调控；基因治疗和治疗性基因组编辑；心血管疾病诊断和管理的系统生物学方法；进行上述任何研究的新方法；以及精准医学的新应用。最重要的是，我们寻求与人类心血管生物学和疾病相关的研究。

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